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AI Advancements in Headache Research: Navigating the Digital Frontier

Edited by:
Gianluca Coppola, MD, PhD, Sapienza University of Rome, Italy
Igor Petrušić, MD, PhD, University of Belgrade, Serbia
 

Submission Status: Open   |   Submission Deadline: 15 June 2025


The Journal of Headache and Pain is calling for submissions to our Collection on AI Advancements in Headache Research: Navigating the Digital Frontier. Explore how cutting-edge AI technologies are transforming migraine research, uncovering intricate neurological insights and personalized treatment approaches.

Image credits: reineg / stock.adobe.com

  1. Migraine ranks as the second-leading cause of global neurological disability, affecting approximately 1.1 billion individuals worldwide with severe quality-of-life impairments. Although adjustable risk factors...

    Authors: Yu-Chen Liu, Ye-Hai Liu, Hai-Feng Pan and Wei Wang
    Citation: The Journal of Headache and Pain 2025 26:103
  2. Migraine is associated with a range of symptoms and comorbid disorders and has a strong genetic basis, but the currently identified risk loci only explain a small portion of the heritability, often termed the ...

    Authors: Fahim Faisal, Antonios Danelakis, Marte-Helene Bjørk, Bendik Winsvold, Manjit Matharu, Parashkev Nachev, Knut Hagen, Erling Tronvik and Anker Stubberud
    Citation: The Journal of Headache and Pain 2025 26:70
  3. Finding a biomarker to diagnose migraine remains a significant challenge in the headache field. Migraine patients exhibit dynamic and recurrent alterations in the brainstem-thalamo-cortical loop, including red...

    Authors: Gabriele Sebastianelli, Daniele Secci, Francesco Casillo, Chiara Abagnale, Cherubino Di Lorenzo, Mariano Serrao, Shuu-Jiun Wang, Fu-Jung Hsiao and Gianluca Coppola
    Citation: The Journal of Headache and Pain 2025 26:67
  4. Migraine is a complex neurological disorder with significant clinical variability, posing challenges for effective management. Multiple treatments are available for migraine, but individual responses vary wide...

    Authors: Qiuyi Chen, Jiarun Zhang, Baicheng Cao, Yihan Hu, Yazhuo Kong, Bin Li and Lu Liu
    Citation: The Journal of Headache and Pain 2025 26:32
  5. Migraine is a complex neurological disorder characterized by recurrent episodes of severe headaches. Although genetic factors have been implicated, the precise molecular mechanisms, particularly gene expressio...

    Authors: Lei Zhang, Yujie Li, Yunhao Xu, Wei Wang and Guangyu Guo
    Citation: The Journal of Headache and Pain 2025 26:14
  6. Inter-individual variability in symptoms and the dynamic nature of brain pathophysiology present significant challenges in constructing a robust diagnostic model for migraine. In this study, we aimed to integr...

    Authors: Jong Young Namgung, Eunchan Noh, Yurim Jang, Mi Ji Lee and Bo-yong Park
    Citation: The Journal of Headache and Pain 2025 26:5
  7. Part 2 explores the transformative potential of artificial intelligence (AI) in addressing the complexities of headache disorders through innovative approaches, including digital twin models, wearable healthca...

    Authors: Igor Petrušić, Chia-Chun Chiang, David Garcia-Azorin, Woo-Seok Ha, Raffaele Ornello, Lanfranco Pellesi, Eloisa Rubio-Beltrán, Ruth Ruscheweyh, Marta Waliszewska-Prosół and William Wells-Gatnik
    Citation: The Journal of Headache and Pain 2025 26:2
  8. To gain a comprehensive understanding of the altered sensory processing in patients with migraine, in this study, we developed an electroencephalography (EEG) protocol for examining brainstem and cortical resp...

    Authors: Fu-Jung Hsiao, Wei-Ta Chen, Hung-Yu Liu, Yu-Te Wu, Yen-Feng Wang, Li-Ling Hope Pan, Kuan-Lin Lai, Shih-Pin Chen, Gianluca Coppola and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2024 25:185
  9. Although gray matter (GM) volume alterations have been extensively documented in previous voxel-based morphometry studies on vestibular migraine (VM), little is known about the impact of this disease on the to...

    Authors: Wen Chen, Hongru Zhao, Qifang Feng, Xing Xiong, Jun Ke, Lingling Dai and Chunhong Hu
    Citation: The Journal of Headache and Pain 2024 25:177
  10. Migraine is a debilitating neurological disorder that presents significant management challenges, resulting in underdiagnosis and inappropriate treatments, leaving patients at risk of medication overuse (MO). ...

    Authors: Teerapong Aramruang, Akshita Malhotra, Pawin Numthavaj, Panu Looareesuwan, Thunyarat Anothaisintawee, Charungthai Dejthevaporn, Nat Sirirutbunkajorn, John Attia and Ammarin Thakkinstian
    Citation: The Journal of Headache and Pain 2024 25:165
  11. Artificial intelligence (AI) is revolutionizing the field of biomedical research and treatment, leveraging machine learning (ML) and advanced algorithms to analyze extensive health and medical data more effici...

    Authors: Igor Petrušić, Woo-Seok Ha, Alejandro Labastida-Ramirez, Roberta Messina, Dilara Onan, Claudio Tana and Wei Wang
    Citation: The Journal of Headache and Pain 2024 25:151

Meet the Guest Editors

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Gianluca Coppola, MD, PhD, Sapienza University of Rome, Italy

Gianluca Coppola, MD, PhD, is a clinical neurologist at Sapienza University of Rome Polo Pontino ICOT. He is a trustee for the International Headache Society and an active member of the Italian Societies for the Study of Headache, of Clinical Neurophysiology, of Neurology, and of Psychophysiology and Cognitive Neurosciences. His research interests include the use of electrophysiology and neuroimaging techniques to understand primary headaches pathophysiology, and to study visual, somatosensory, and motor systems synaptic plasticity mechanisms.

Igor Petrušić, MD PhD, University of Belgrade, Serbia

Igor Petrušić MD, PhD, (radiologist, pain medicine specialist trainee, and clinical neuroscientist) is a senior research associate at the Laboratory for advanced analysis of neuroimages, Faculty of Physical Chemistry, University of Belgrade, Serbia. He has a great interest in developing electrophysiological and neuroimaging protocols in migraine with aura research, primarily focused on discovering biomarkers for different levels of migraine aura complexity. He also aims to incorporate a multidisciplinary approach in headache research to boost advancements in the diagnosis and prediction of treatment outcomes.

About the Collection

The Collection entitled "AI Advancements in Headache Research: Navigating the Digital Frontier” delves into the intersection of machine learning technologies and migraine research, aiming to elucidate the intricate neurological aspects of migraine disorders. This Collection focuses on how advanced machine learning algorithms and computational techniques, as well as digital twin’s solutions, are being applied to analyze vast clinical, neurophysiological, and neuroimaging datasets, uncover patterns, and discern nuanced relationships within the complex landscape of migraine-related phenomena.

Researchers leverage machine learning to sift through diverse factors influencing migraines, such as genetic predispositions, environmental triggers, and individualized symptomatology. The Collection explores the transformative potential of machine learning in deciphering the multifaceted nature of migraines, shedding light on elusive patterns that traditional research methods might overlook.

Moreover, the Collection would like to emphasize the role of machine learning models in enhancing diagnostic accuracy, predicting migraine occurrences, and personalizing treatment approaches. By unravelling the neurological intricacies of migraines through innovative computational methods, this thematic Collection aims to underscore the promising advancements that machine learning brings to the forefront of migraine studies, providing a deeper understanding of these disorders and paving the way for more effective interventions.

Nevertheless, this Collection is open to discussing the possible ethical implications of a diagnostic-therapeutic approach based solely or partly on artificial intelligence results. The goal is to effectively and ethically improve the diagnostic quality and therapeutic approach to treating primary headaches.

Submission Guidelines

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This Collection welcomes submission of  original research and review papers. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. 

Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “AI Advancements in Headache Research: Navigating the Digital Frontier" under the “Details” tab during the submission stage.

Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.