Zhen Dong, PhD, Westlake University, China
Proteome Science is calling for submissions to our new Collection on Advances in Single-Cell and Spatial Proteomics. This Collection explores the advancements and integration of single-cell and spatial proteomics, highlighting their impact on understanding cellular heterogeneity, tissue architecture, and molecular functions across diverse biological contexts.
Single-cell and spatial proteomics are rapidly evolving, enabling high-resolution analysis of proteins within individual cells and their native tissue environments. These complementary approaches provide deep insights into cellular heterogeneity, tissue architecture, and molecular function.
Recent advances from high-throughput sample preparation to ultra-sensitive mass spectrometry and AI-driven analysis are driving progress in both fields and fostering increasing integration, with single-cell proteomics achieving greater proteome depth and throughput at the individual cell level, and spatial proteomics approaching single-cell and even subcellular resolution. Together, they support precise mapping of protein expression, localization, and interaction networks across diverse biological contexts, including development, cancer, and neuroscience.
As these technologies become increasingly accessible and scalable, they are transforming how we study biological systems in situ, offering a proteomic counterpart to the success of single-cell and spatial transcriptomics in resolving the complexity of life at cellular and tissue scales.
There are currently no articles in this collection.
This Collection welcomes submissions of original research and review articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal.
Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “Advances in Single-Cell and Spatial Proteomics" under the “Details” tab during the submission stage.
Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.
The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.