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The Exosome Collection

Edited by:

Professor Steven R. Goodman, PhD, University of Tennessee Health Science Center, United States
Professor Aleksander F Sikorski, PhD, DSc, University of Wrocław, Poland
 

Submission Status: Open   


Cellular & Molecular Biology Letters has assembled a Collection of its recently published primary research and review articles on the important topic of exosomes and their roles in disease etiology, diagnosis and monitoring of progression, therapeutics, and current and future applications in regenerative medicine. Exosomes from mesenchymal stem cells or mesenchymal stromal cells (MSCs) are involved in tissue and organ rejuvenation and regeneration, as well as normal cellular physiology and homeostasis. But exosomes derived from infected, or disease associated cells tend to mediate pathogenesis. We find examples of both situations in this Collection of articles which the Editorial Board hopes you enjoy reading and we hope to expand upon in the future.

Image credit: © JUAN GAERTNER/SCIENCE PHOTO LIBRARY

Meet the Guest Editors

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Professor Steven R. Goodman, PhD, University of Tennessee Health Science Center, United States

Steven R. Goodman, Ph.D. served as Vice Chancellor for Research at The University of Tennessee Health Science Center (UTHSC), from July 2015 to January 2023, during which time the Institution reached its highest level of annual Grants and Contracts. Dr. Goodman currently serves as a tenured Professor in the Departments of Pediatrics with a joint appointment in Physiology within the UTHSC College of Medicine. Dr. Goodman led the creation of the Clinical Trials Network of Tennessee (CTN2) and served as the President and CEO of CTN2. He also led the creation of the Tennessee Institute of Regenerative Medicine. Steve is known globally for his research into the structure and function of cell structures called membrane skeletons. His laboratory worked out many of the interactions within the red blood cell membrane skeleton, including the identification of the spectrin binding protein now called ankyrin, discovered non-erythroid spectrin and first described the spectrin isoforms and their structure and functions within the diverse cells.  As Director of NHLBI Sickle Cell Centers his research into sickle cell disease led to defining the molecular basis of the irreversibly sickle cell and his proteomic studies included the study of the human erythrocyte proteome, changes in the Sickle Cell proteome, and led to the seminal candidate biomarkers for sickle cell severity. Dr. Goodman’s research accomplishments were made possible by over $20 million in extramural funding and led to approximately one hundred and seven five peer reviewed publications. He is a recipient of the Society of Experimental Biology and Medicine (SEBM) Distinguished Scientist Award and was elected as a 2016 American Association for the Advancement of Science (AAAS) Fellow. Steve is a Past President of the Association of Anatomy, Cell Biology and Neurobiology Chairs (AACBNC). He has served on multiple Boards including the Alliance for Cell Therapy Now. The 4th Edition of his textbook Goodman’s Medical Cell Biology became available in July 2020. Dr. Goodman serves on multiple editorial boards, including Cell and Molecular Biology Letters, and served as Editor-in-Chief of Experimental Biology and Medicine (EBM) for eighteen years beginning in 2006.  As Editor-in-Chief of EBM, Dr. Goodman globalized EBM and SEBM opening offices in six continents. He also increased the scientific topics of the journal to 22 categories covering the breadth of modern biomedical research including all translational stages from T0 to T4, basic research to population health.


Professor Aleksander F Sikorski, PhD, DSc, University of Wrocław, Poland

Aleksander F Sikorski is a retired professor in biochemistry and cell biology at the University of Wrocław, now working at the Research and Development Centre, Regional Specialist Hospital in Wrocław, and at Acellmed, a small drug-developing company. His main scientific interest is membrane biochemistry, particularly the lateral organization of biological membranes and liposomes as drug carriers. He has authored and co-authored over 130 scientific papers and supervised 28 PhD graduates.
 

  2. Exosomes are nano-sized membrane extracellular vesicles which can be released from various types of cells. Exosomes originating from inflammatory or injured cells can have detrimental effects on recipient cell...

    Authors: Zeinab Vahidinia, Abolfazl Azami Tameh, Shirin Barati, Melika Izadpanah and Elahe Seyed Hosseini
    Citation: Cellular & Molecular Biology Letters 2024 29:30
    Content type: Mini Review Published on:

  3. Hypervirulent Klebsiella pneumoniae (hvKp) infection-induced sepsis-associated acute lung injury (ALI) has emerged as a significant clinical challenge. Increasing evidence suggests that activated inflammatory mac...

    Authors: Yihan Xu, Chunying Zhang, Danni Cai, Rongping Zhu and Yingping Cao
    Citation: Cellular & Molecular Biology Letters 2023 28:92
    Content type: Research Article Published on:

  4. Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main pathological change, is the major source of pain and disability worldwide. Despite current treatments, the overall ...

    Authors: Zehao Zhang, Sheng Zhao, Zhaofeng Sun, Chuanxing Zhai, Jiang Xia, Caining Wen, Yuge Zhang and Yuanmin Zhang
    Citation: Cellular & Molecular Biology Letters 2023 28:75
    Content type: Review Letter Published on:

  5. Sepsis is an abnormal immune response after infection, wherein the lung is the most susceptible organ to fail, leading to acute lung injury. To overcome the limitations of current therapeutic strategies and de...

    Authors: Guo-wei Tu, Yi Zhang, Jie-fei Ma, Jun-yi Hou, Guang-wei Hao, Ying Su, Jing-chao Luo, Lulu Sheng and Zhe Luo
    Citation: Cellular & Molecular Biology Letters 2023 28:24
    Content type: Research Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2024 29:133

  6. Brain microvascular endothelial cell (BMEC) injury can affect neuronal survival by modulating immune responses through the microenvironment. Exosomes are important vehicles of transport between cells. However,...

    Authors: Mengqi Zhang, Qian Wu, Mimi Tang, Zhuohui Chen and Haiyue Wu
    Citation: Cellular & Molecular Biology Letters 2023 28:18
    Content type: Research Letter Published on:

  7. Esophageal squamous carcinoma (ESCC) is a common malignancy that originates in the digestive tract. Lymph node metastasis (LNM) is a complicated process, and tumor lymphangiogenesis has been reported to be ass...

    Authors: Wenjian Yao, Xiangbo Jia, Li Zhu, Lei Xu, Quan Zhang, Tian Xia and Li Wei
    Citation: Cellular & Molecular Biology Letters 2023 28:13
    Content type: Research Published on:

  8. Kidney insults due to various pathogenic factors, such as trauma, infection, and inflammation, can cause tubular epithelial cell injury and death, leading to acute kidney injury and the transformation of acute...

    Authors: Yihang Yu, Meiling Chen, Qitong Guo, Lianju Shen, Xing Liu, Jianbo Pan, Yuanyuan Zhang, Tao Xu, Deying Zhang and Guanghui Wei
    Citation: Cellular & Molecular Biology Letters 2023 28:12
    Content type: Research Published on: