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Global Burden of Disease Findings affecting Health Spending - Projections and Forecasts towards 2050

Edited by:

Mihajlo (Michael) Jakovljevic, MD, PhD, MAE, University of Kragujevac, Serbia
Hao Hu, PhD, University of Macau, China

Submission Status: Open   |   Submission Deadline: 20 November 2025

Cost Effectiveness and Resource Allocation is calling for submissions to our Collection on Global Burden of Disease Findings affecting Health Spending - Projections and Forecasts towards 2050. The collection welcomes original articles on topics such as:

  • Long-term financial challenges for healthcare systems
  • Approaches to managing rising healthcare costs
  • Transition from industrial revolution-driven growth
  • Declining fertility rates in Sub-Saharan Africa and Afghanistan
  • Co-existence of infectious and non-communicable diseases
  • Healthcare challenges in low- and middle-income nations
  • Challenges posed by aging populations
  • Implications for healthcare access and affordability
  • Disparities in healthcare access due to income inequalities
  • Shared healthcare challenges in wealthy and low-income countries
  • Economic implications for healthcare in post-industrial economies
  • Effect of the shrinking middle class on healthcare affordability
  • Role of AI-assisted medical devices in healthcare systems
  • Cost implications of healthcare robotics and automation
  • The rise of genomics-based pharmaceuticals
  • Financial impact on healthcare systems
  • Exploring future financial sustainability strategies for healthcare
  • Contributions to tackling future challenges in global health system

Image credit: © Yevhen Roshchyn / stock.adobe.com

New Content ItemThis Collection supports and amplifies research related to SDG 3: Good Health & Well-Being.

About the Collection

Global Burden of Disease Project, has revealed hidden healthcare financial sustainability transformation as we approach 2050. Demographic growth Era driven by industrial revolutions, advanced agriculture and modern medicine ends, with Sub-Saharan Africa and Afghanistan being the last springs of high fertility. The Global South nations bear the double burden of infectious and non-communicable diseases. Population aging and income inequalities continue to threaten medical care accessibility and affordability. Surprisingly, due to the shrinking middle class in wealthy, post-industrial economies, this trend is shared with low-and-middle-income countries. Advent of artificial intelligence-assisted medical devices and healthcare robotics, coupled with genomics pharmaceuticals are about to be major cost drivers. We welcome contributions focusing on these long-term financial sustainability challenges facing contemporary and future health systems.

Meet the Guest Editors

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Mihajlo (Michael) Jakovljevic, MD, PhD, MAE, University of Kragujevac, Serbia

Professor Mihajlo (Michael) Jakovljevic MD, PhD, MAE is a Top-Notch expert in the Economics of Global Health. This is witnessed with а 20 years long track record of service on behalf of various UN bodies and leading multilateral agencies such as UNESCO, WHO, GBD Project, European Commission, SNSF, JSPS etc. His primary focus of interest remains on health financing and affordability issues in the Global South's LMICs countries and the Emerging Markets. Being a professional health economist and a clinical pharmacology physician, his work is largely applicable to sustainable healthcare investment from the perspective of governing authorities, pharmaceutical and medical device industries. 
As of 2018, by the decision of WHO Director Regional, he was appointed top-tier EACHR Committee Member with WHO Regional Office for Europe in Copenhagen, Denmark. In 2021 he was elected UNESCO – TWAS Ordinary Fellow in the leading UN forum for Sustainable Development of the Global South. Academia Europaea, London, UK elected him 2022 as the first national representative to the Section Clinical and Veterinary Medicine composed of almost 800 members from all of the European continent. So far he was holding Visiting / Affiliated positions at Hosei University Tokyo, (Institute for Comparative Economic Studies / Japanese National Center for Population Aging); CHTF IHME University of Washington, USA; Health Economics Department, Lund University, Sweden; Vienna Medical University, Austria, Ghent University, Belgium etc. For his deeds and professional standing, in spring 2015 he was the only ever nominated candidate for IHEA *(International Health Economics Association) Board of Directors Elections, based in Eastern Europe. 

Hao Hu, PhD, University of Macau, China

Hao Hu is a professor of biomedical data science and medicinal administration at the Institute of Chinese Medical Sciences and the Faculty of Health Sciences at the University of Macau. He is the author of five books and has contributed over 300 articles to peer-reviewed journals. His research interests encompass bioinformatics and computational drug discovery, pharmacoeconomics and pharmacoepidemiology, and pharmaceutical industry and policy. Through his work, he has produced pharmacological, clinical, and policy evidence to address various health conditions, including cancer, diabetes, obesity, NASH (non-alcoholic steatohepatitis), and COPD (chronic obstructive pulmonary disease). Recently, he has been particularly interested in utilizing advanced data science techniques in biomedicine and Chinese medicine, especially regarding rare cancers. 


There are currently no articles in this collection.

Submission Guidelines

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This Collection welcomes submission of original research articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. 

Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “Global Burden of Disease Findings affecting Health Spending - Projections and Forecasts towards 2050" under the “Details” tab during the submission stage.

Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.