Rare cancers often exhibit distinct genetic alterations that set them apart from more prevalent malignancies. These differences not only create challenges in diagnosis and prognosis but also offer unique opportunities for the development of targeted therapies. Recent advancements in pathology, such as enhanced morphological evaluations and advanced genetic profiling, have provided valuable insights into the clinical behavior of these cancers, improving our ability to customize treatment strategies.
Ongoing research in this field has the potential to reveal novel biomarkers and develop innovative therapeutic approaches that could significantly enhance patient outcomes. For instance, breakthroughs in understanding the molecular mechanisms underlying Hodgkin lymphoma and other rare cancers may lead to highly personalized treatment regimens that markedly improve survival rates. By focusing on rare cancers, we ensure that these less common but equally important malignancies receive the necessary attention and resources for research and treatment.
We invite researchers to contribute to this special Collection by submitting original research articles, reviews, and case reports. Rare cancers may include but are not limited to Hodgkin lymphoma, ocular or acral lentiginous melanoma, penile cancer, vaginal cancer, esophageal cancer, and sarcomas. Topics of interest include, but are not limited to:
• Genetic profiling of rare cancers
• Targeted therapy advancements
• Clinical outcomes
• Predictive and prognostic markers
• Morphological variations in rare malignancies
• Diagnostic molecular pathology of rare tumors
• Novel treatment strategies for unique genetic changes in rare cancers
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