Guest Editors:
Christine D. Keating, PhD, Penn State University, United States
Gian Gaetano Tartaglia, PhD, Italian Institute of Technology, Italy
Genome Biology called for submissions to our Collection on all aspects of subcellular organization, mechanisms, and interactions.
Christine D. Keating, PhD, Penn State University, United States
Dr Keating is the Shapiro Professor of Chemistry at Penn State University, USA. Her research interests combine materials science, physical chemistry, and cell biology with a focus on compartmentalization by liquid-liquid phase coexistence and its functional consequences in biology, artificial cells and prebiotic scenarios.
Gian Gaetano Tartaglia, PhD, Italian Institute of Technology, Italy
Dr Tartaglia studied biophysics at University Sapienza, Italy (1995-2000), and transitioned to protein folding and aggregation studies in Zurich, Switzerland (2001-2005) and Cambridge UK (2005-2010). He then continued as a PI at Centre for Genomic Regulation (CRG) Barcelona, pioneering in amyloid genes regulation (2010-2020). Joining IIT in Italy (2020-present), he leads the RNA System Biology lab, focusing on proteins and non-coding RNAs affecting transcription, translation, and neurodisorders. Supported by an ERC grant, his lab unravels the mysteries of altered phase transitions, with breakthroughs in RNA's role in ribonucleic assemblies and phase separation, illuminating cellular biology and viral infection dynamics. Their insights are pivotal for artificial RNAs design, targeting protein condensation in disorders like ALS.
Genome Biology is calling for submissions to our Collection on intracellular compartments.
Compartmentalization plays an essential role in maintaining cellular processes and functions. The spatial segregation within cells leads to the formation of distinct biophysical environments within the cell, allowing the concentration of specific molecules and enabling various cellular processes, such as gene expression and signal transduction. These compartments include the recently discovered membraneless organelles formed by phase separation, which lack a traditional lipid bilayer and serve as dynamic hubs for a range of cellular activities.
This collection aims to gather original research and methodological articles that delve into the multifaceted aspects of subcellular organization. It welcomes computational and experimental studies exploring the mechanisms behind the formation and function of these compartments, their interactions with other cellular components, and their impact on overall cell physiology in the context of genome biology. Moreover, articles that synthesize complex biological data to offer a more comprehensive understanding of these processes are highly encouraged.
Such research is not only crucial for advancing our fundamental understanding of cell biology but also has potential implications in understanding diseases linked to dysfunctions in cellular compartmentalization. By exploring these novel aspects of cellular organization, the collection aims to contribute significantly to the broader field of cellular and molecular biology. Topics accepted for submission include, but are not limited to:
Image credit: Christoph Burgstedt / stock.adobe.com
The tight correlation between topologically associating domains (TADs) and epigenetic domains in Drosophila suggests that the epigenome contributes to define TADs. However, it is still unknown whether histone mod...
Fork-head box protein M1 (FOXM1) plays critical roles in development and progression of multiple cancers, including hepatocellular carcinoma (HCC). However, the exact regulatory hierarchy of FOXM1 remains uncl...
Eukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various biological ...
Liquid-liquid phase separation (LLPS) enables the formation of membraneless organelles, essential for cellular organization and implicated in diseases. We introduce catGRANULE 2.0 ROBOT, an algorithm integrati...
This Collection welcomes submission of original Research, Method, Short Report, Review, and Database article types. Before submitting your manuscript, please ensure you have read our submission guidelines.
To submit your manuscript to this Collection, please use our online submission system and indicate in your covering letter that you would like the article to be considered for inclusion in the "Subcellular Compartmentalization" Collection.
All articles submitted to Collections are peer reviewed in line with the journal’s standard peer review policy and are subject to all of the journal’s standard editorial and publishing policies. This includes the journal’s policy on competing interests.
The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editor or Editorial Board Member who has no competing interests.