Thrombosis Journal is calling for submissions to our Collection on Thiol-based Redox Regulation of Thrombosis. Thrombosis is currently the leading cause of death in many diseased conditions; however, its mechanism remains largely elusive. It has been known that thiol-disulfide exchange dramatically and quickly change the function of critical hemostatic proteins, such as platelet GPIb, integrins aIIbb3 and a2b1, tissue factor, coagulation factor XI, fibrinogen, von Willebrand factor, histidine-rich glycoprotein, and thrombospondin etc. Therefore, it is important to understand the enzymes that regulates these dynamic thiol-based post-translational modifications. Recent studies show several thiol oxidoreductases including PDI, ERp5, ERp57, ERp46, ERp72 support thrombosis, but TMX1 has an inhibitory role, demonstrating that prothrombotic and antithrombotic thiol isomerases are central elements of redox balance controlling thrombosis. However, we are in the early stages of our investigation of the complex regulation, and many outstanding questions still remain: Do other thiol oxidoreductases contribute to thrombosis? What are their substrates and targeting cysteine/disulfides? Do they function in parallel or cooperatively? Whether and how do they contribute to the pathogenesis of thrombotic diseases? This collection aims to gather contributions that enhance our knowledge on these topics that may include:
• Identification of new thiol oxidoreductases in positive and negative regulation of platelet, coagulation and anti-coagulation factors, fibrinolytic enzymes, and other plasma and matrix proteins, as well as the interaction and cross-talks of thiol oxidoreductases.
• Thiol-based integration mechanism of platelet activation and coagulation system, for initiation, propagation and self-limitation of thrombosis.
• New chemical tools and methodology development to evaluate redox state of thiol oxidoreductases and their targeting substrates and cysteines/disulfides in vivo and in vitro.
• Thiol oxidoreductases as therapeutic target for thrombotic diseases.
