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Molecules of Neural Disorders

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Reviews in this themed series were commissioned by Professors Tim Bliss, Satoshi Kida and Graham Collingridge.
All submissions were handled by Tim Bliss and were independently and externally peer-reviewed.   

  1. Following intracerebral hemorrhage, mitigating oxidative stress and removing excess iron are critical strategies for reducing secondary brain injury and improving neurological outcomes. In vitro, we synthesize...

    Authors: Guangyu Jia, Xinyu Yang, Yamei Yu, Yuanyuan Li, Zhe Zhang, Xiaolong Tang, Qi Wang, Heqing Zheng, Yao Xiao, Shiyong Li and Ye Wang
    Citation: Molecular Brain 2025 18:17
    Content type: Research Published on:

  2. The present study uses electron microscopy to document ultrastructural characteristics of hippocampal GABAergic inhibitory synapses under resting and stimulated conditions in three experimental systems. Synapt...

    Authors: Jung-Hwa Tao-Cheng, Sandra Lara Moreira and Christine A. Winters
    Citation: Molecular Brain 2024 17:76
    Content type: Research Published on:

  3. Abnormal white matter is a common neurobiological change in bipolar disorder, and dysregulation of myelination in oligodendrocytes (OLs) is the cause. Transmembrane protein 108 (Tmem108), as a susceptible gene of...

    Authors: Yongqiang Wu, Yanzi Zhong, Xufeng Liao, Xiangguang Miao, Jianbo Yu, Xinsheng Lai, Yu Zhang, Chaolin Ma, Haili Pan and Shunqi Wang
    Citation: Molecular Brain 2022 15:33
    Content type: Research Published on:

  5. Psychoneuroimmunological studies have clearly demonstrated that both cellular and humoral immunity are related to major depression. Soluble ST2 is regarded as a key molecule regulating immune system as well as...

    Authors: Motoshi Kikuchi, Kenkichi Takase, Morisada Hayakawa, Hiroko Hayakawa, Shin-ichi Tominaga and Tsukasa Ohmori
    Citation: Molecular Brain 2020 13:74
    Content type: Research Published on:

  6. Anxiety disorder is highly prevalent worldwide and represents a chronic and functionally disabling condition, with high levels of psychological stress characterized by cognitive and physiological symptoms. Sco...

    Authors: Li Luo, Ting Sun, Le Yang, An Liu, Qing-qing Liu, Qin-qin Tian, Yan Wang, Ming-gao Zhao and Qi Yang
    Citation: Molecular Brain 2020 13:15
    Content type: Research Published on:

  7. Alzheimer’s disease (AD) is the most devastating neurodegenerative disorder. Due to the increase in population and longevity, incidence will triple by the middle of the twenty-first century. So far, no treatme...

    Authors: Yingshuo Xu, Guiran Xiao, Li Liu and Minglin Lang
    Citation: Molecular Brain 2019 12:106
    Content type: Review Published on:

  9. Protein phosphorylation plays an important role in learning and memory. Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in the regulation of neural synaptic plasticity. Here, to determ...

    Authors: Jing Wang, Ran Xie, Xiaolin Kou, Yu Liu, Cui Qi, Rui Liu, Weiyan You, Jun Gao and Xiang Gao
    Citation: Molecular Brain 2019 12:51
    Content type: Research Published on:

  10. The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer’s disease (AD) pathology. Thus, the approach toward Aβ metabolism is considered to play a critical role in the onset an...

    Authors: Yasuha Noda, Akira Kuzuya, Kyousuke Tanigawa, Mitsugu Araki, Ryoko Kawai, Biao Ma, Yoko Sasakura, Masato Maesako, Yoshitaka Tashiro, Masakazu Miyamoto, Kengo Uemura, Yasushi Okuno and Ayae Kinoshita
    Citation: Molecular Brain 2018 11:61
    Content type: Research Published on:

  12. The 18 kDa translocator protein (TSPO) is primarily localized in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. One of the protein’s main function...

    Authors: Xu-bo Li, An Liu, Le Yang, Kun Zhang, Yu-mei Wu, Ming-gao Zhao and Shui-bing Liu
    Citation: Molecular Brain 2018 11:12
    Content type: Research Published on:

  13. Memory consolidation, reconsolidation, and extinction have been shown to share similar molecular signatures, including new gene expression. Calpain is a Ca2+-dependent protease that exerts its effects through the...

    Authors: Taikai Nagayoshi, Kiichiro Isoda, Nori Mamiya and Satoshi Kida
    Citation: Molecular Brain 2017 10:61
    Content type: Research Published on:

  15. Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly...

    Authors: Christine N. Yohn, Mark M. Gergues and Benjamin Adam Samuels
    Citation: Molecular Brain 2017 10:28
    Content type: Review Published on:

  16. Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in norma...

    Authors: Robert Nisticò, Eric Salter, Celine Nicolas, Marco Feligioni, Dalila Mango, Zuner A. Bortolotto, Pierre Gressens, Graham L. Collingridge and Stephane Peineau
    Citation: Molecular Brain 2017 10:26
    Content type: Review Published on:

  17. Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagat...

    Authors: Michel Goedert and Maria Grazia Spillantini
    Citation: Molecular Brain 2017 10:18
    Content type: Review Published on:

  18. The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo ...

    Authors: Min Zhuo
    Citation: Molecular Brain 2017 10:16
    Content type: Review Published on:

  20. Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the central nervous system. Dysregulation of microglia has been critically implicated in the genesis of neuropathic pain. Per...

    Authors: Josiane C. S. Mapplebeck, Simon Beggs and Michael W. Salter
    Citation: Molecular Brain 2017 10:9
    Content type: Review Published on:

  22. Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social cognition, language development, and repetitive/restricted behaviors. Due to the complexity and heter...

    Authors: Chae-Seok Lim, Jung-eun Yang, You-Kyung Lee, Kyungmin Lee, Jin-A Lee and Bong-Kiun Kaang
    Citation: Molecular Brain 2015 8:57
    Content type: Review Published on: