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Precision Medicine and Epilepsy

Precision Medicine is the practice of making tailored healthcare and clinical decisions to patients based on their intrinsic biological information as well as clinical symptoms and signs. In recent years, the genetic research and precise diagnosis and treatment of epilepsy have gradually become the fastest growing research direction in the field of epilepsy. The application of precision medicine in epilepsy aims to play an important role in the diagnosis and treatment of epilepsy according to the associated genes and specific molecular changes, so as to provide individual treatment strategies for patients with epilepsy.

Guest Editor

Guest EditorProf.  Weiping Liao

Professor of department of neurology in Guangzhou Medical University, director of Institute of Neuroscience of Guangzhou Medical University, and director of Key Laboratory of Neurogenetics and Ion Channel Disease of the Ministry of Education. 

He is currently the chairman of the Precision Medicine and Adverse Drug Reaction Monitoring Committee of China Anti-Epilepsy Association, the Government Special Subsidy Expert of the State Council, the Epilepsy Ambassador of the International League Against Epilepsy (ILAE), the Chairman of the ILAE Education Working Committee, and the Associated Editor-in-Chief of Seizure.

This series was published in Acta Epileptologica.

Here are the articles in the series:

  1. The Midasin AAA (ATPase associated with various activities) ATPase 1 (MDN1) gene, a member of the AAA protein family, plays a crucial role in ribosome maturation. MDN1 is expressed in the human brain throughout l...

    Authors: Qianru Wen, Dongming Zhang, Yan Ding, Sheng Luo, Qiang Huang, Junhui Zhu, Yongxin Li, Wenhui Liu, Pengyu Wang, Xian Li, Zisheng Lin, Yaying Wang, Xiaoyu Liang, Weiping Liao, Jie Wang and Heng Meng
    Citation: Acta Epileptologica 2025 7:17
    Content type: Research Published on:

  2. Developmental and epileptic encephalopathy (DEE) is a group of neurodevelopmental disorders characterized by early-onset seizures predominantly attributed to genetic causes. Nevertheless, numerous patients rem...

    Authors: Wenwei Liu, Kai Gao, Xilong Du, Sijia Wen, Huifang Yan, Jingmin Wang, Yong Wang, Conglei Song, Li Lin, Taoyun Ji, Weiyue Gu and Yuwu Jiang
    Citation: Acta Epileptologica 2024 6:42
    Content type: Research Published on:

  3. The TSC1 gene encodes a growth inhibitory protein hamartin, which plays a crucial role in negative regulation of the activity of mTORC1 (mechanistic target of rapamycin complex 1). TSC1 has been associated with t...

    Authors: Nanxiang Shen, Zhihong Zhuo, Xiangyun Luo, Bingmei Li, Xuqing Lin, Sheng Luo, Zilong Ye, Pengyu Wang, Na He, Yiwu Shi and Weiping Liao
    Citation: Acta Epileptologica 2024 6:41
    Content type: Research Published on:

  4. SCN1A is the most well-recognized and commonly mutated gene related to epilepsy. This study analyzed the characteristic spatial and frequency distributions of SCN1A mutations, aiming to provide important insight ...

    Authors: Mengwen Zhang, Jing Guo, Bin Li, Kang Liu, Jiayuan Zhao, Jiayuan Zhang, Xuqing Lin, Bin Tang, Jie Wang, Weiping Liao and Na He
    Citation: Acta Epileptologica 2024 6:37
    Content type: Research Published on:

  5. The SLC2A1 gene plays a vital role in brain energy metabolism. SLC2A1 variants have been reported to be associated with early-onset refractory seizures. This study aims to explore the association between the SLC2...

    Authors: Dongming Zhang, Jing Guo, Zisheng Lin, Hongjun Yan, Kai Peng, Linxia Fei, Qiongxiang Zhai, Dongfang Zou, Jiayi Zhong, Yan Ding, Hong Ye, Pengyu Wang, Jie Wang, Sheng Luo, Bingmei Li, Bin Li…
    Citation: Acta Epileptologica 2024 6:38
    Content type: Research Published on:

  7. Epilepsy can be caused by a variety of causes, such as inborn errors of metabolism, organic acid disorders are the most significant type of metabolic disorders that cause seizures. The clinical manifestations ...

    Authors: Yuqing Shi, Zihan Wei, Yan Feng, Yajing Gan, Guoyan Li and Yanchun Deng
    Citation: Acta Epileptologica 2024 6:24
    Content type: Review Published on:

  8. NR2F1 mutations are associated with Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS). Although ~ 46.7% of BBSOAS patients present with epilepsy, which is always drug-resistant and associated with higher rate...

    Authors: Xiao Li, Kai Gao, Yutang Li, Yuehua Zhang, Han Zhang and Yuwu Jiang
    Citation: Acta Epileptologica 2024 6:3
    Content type: Research Published on:

  10. The genetic generalized epilepsies (GGEs) have been proved to generate from genetic impact by twin studies and family studies. The genetic mechanisms of generalized epilepsies are always updating over time. Al...

    Authors: Xiaoqian Wang, Xueyi Rao, Jia Zhang and Jing Gan
    Citation: Acta Epileptologica 2023 5:8
    Content type: Review Published on: