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Regulation of gene expression through RNA

Guest Editors

Marco Mangone, PhD, Arizona State University, USA
Gian Gaetano Tartaglia, PhD, Istituto Italiano di Tecnologia (IIT), Italy


BMC Biology called for submissions to our Collection on Regulation of gene expression through RNA. Forms of RNA-mediated regulation include the role of small RNAs in gene silencing, function modulation via RNA binding proteins, regulation of translation via small RNA interference, and alternative splicing events, among many others.

This Collection welcomed submissions covering updates and advancements in better understanding mechanisms of post-transcriptional regulation, as well as the impact of misregulation in the context of disease and evolution.

Meet the Guest Editors

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Marco Mangone, PhD, Arizona State University, USA

Dr Mangone studies how eukaryotic RNA transcription is terminated and how the messenger RNA is regulated on its way to the expression into proteins, using the wound worm C. elegans as a model system. His research combines high-throughput genomics, bioinformatics, genetics, biochemistry, and systems biology and focuses on the characterization of 3' Untranslated Regions, and alternative polyadenylation events, with the ultimate goal of identifying cis-regulatory elements targeted by non-coding RNAs and proteins that bind and repress the translation of the mRNA into protein.

Gian Gaetano Tartaglia, PhD, Istituto Italiano di Tecnologia (IIT), Italy

Dr Tartaglia graduated from University La Sapienza, specializing in mathematical modeling of neurons, and later did his doctorate at the University of Zurich, which focused on protein folding related to neurodegenerative diseases. Subsequently, he delved into computational and experimental studies on amyloidosis at the University of Cambridge. As a PI at CRG Barcelona, Dr Tartaglia received an ERC grant in 2013 for research on RNA interactions with amyloid genes. Tenured as an ICREA professor in 2014, he became a Biochemistry professor at La Sapienza in 2018, joining IIT in 2019. His work, awarded an ERC grant in 2020, focuses on ribonucleoprotein interactions, elucidating their role in orchestrating post-transcriptional events and gene expression. Since September 2020, Dr Tartaglia is a Member of Academia Europaea (MAE).


About the Collection

BMC Biology is calling for submissions to our Collection on Regulation of gene expression through RNA. Forms of RNA-mediated regulation include the role of small RNAs in gene silencing, function modulation via RNA binding proteins, regulation of translation via small RNA interference, and alternative splicing events, among many others.

Post-transcriptional regulation mechanisms can affect adaptive divergence and evolution, and their misregulation can be at the center of disease onset and progression, making them suitable targets for therapeutic intervention.

This Collection welcomes submissions covering updates and advancements in better understanding mechanisms of post-transcriptional regulation, as well as the impact of misregulation in the context of disease and evolution.

Topics may include, but are not limited to:

  • Post-transcriptional events governing RNA stability and processing
  • Mechanisms of siRNAs and miRNAs in gene silencing
  • Impact of RNA binding proteins on gene expression
  • Post-transcriptional gene regulation by long non-coding RNAs
  • RNA-mediated gene regulation in disease and evolution
  • Therapeutic approaches targeting post-transcriptional regulation
  • RNA therapeutics


Image credit: [M] Artur Plawgo / Getty Images / iStock

  1. The information content within nucleic acids extends beyond the primary sequence to include secondary structures with functional roles in transcription regulation. Guanine-rich sequences form structures called...

    Authors: Ryan J. Snyder, Uma Shankar, Don Delker, Winny Soerianto, Joshua T. Burdick, Vivian G. Cheung and Jason A. Watts
    Citation: BMC Biology 2025 23:129
    Content type: Research Published on:

  3. Acute lung injury (ALI) which is caused by Staphylococcus aureus (SA), is a serious lung disease that threatens human health. Although some current treatments are effective in alleviating ALI, they still have a s...

    Authors: Yan Xiong, Lulu Wang, Bohao Li, Beibei Fu, Zhou Sha, Jin Liu, Rong Tian, Rui Yao, Feng Lin, Zixuan Cong, Yongliang Du, Xiaoyuan Lin and Haibo Wu
    Citation: BMC Biology 2025 23:90
    Content type: Research Published on:

  4. Aspergillus fumigatus, the primary etiological agent of invasive aspergillosis, causes over 1.8 million deaths annually. Targeting cell wall biosynthetic pathways offers a promising antifungal strategy. Gfa1, a r...

    Authors: Qijian Qin, Pingzhen Wei, Sayed Usman, Chukwuemeka Samson Ahamefule, Cheng Jin, Bin Wang, Kaizhou Yan, Daan M. F. van Aalten and Wenxia Fang
    Citation: BMC Biology 2025 23:80
    Content type: Research Published on:

  5. Thermotolerance is a critical trait for yeasts employed in industrial settings, and the utilization of unconventional yeasts has gained notable attention in recent years. However, the mechanisms underlying the...

    Authors: Yanhua Qi, Qijian Qin, Jiayin Ma, Bin Wang, Cheng Jin and Wenxia Fang
    Citation: BMC Biology 2025 23:55
    Content type: Research Published on:

  6. Aging is a natural process that affects the majority of organs within the organism. The liver, however, plays a pivotal role in maintaining the organism's homeostasis due to its robust regenerative and metabol...

    Authors: Ye Jin, Gaoge Sun, Binxian Chen, Siqin Feng, Muyun Tang, Hui Wang, Ying Zhang, Yuan Wang, Yang An, Yu Xiao, Zihan Liu, Peng Liu, Zhuang Tian, Hang Yin, Shuyang Zhang and Xiaodong Luan
    Citation: BMC Biology 2025 23:41
    Content type: Research article Published on:

  7. HuR/ELAV1, a ubiquitous RNA-binding protein, belongs to the RNA-binding protein family and is crucial for stabilizing and regulating the translation of various mRNA targets, influencing gene expression. Elevat...

    Authors: Nathalie Idlin, Sivakumar Krishnamoorthy, Magdalena Wolczyk, Mouad Fakhri, Michal Lechowski, Natalia Stec, Jacek Milek, Pratik Kumar Mandal, Jaroslaw Cendrowski, Christos Spanos, Magdalena Dziembowska, Katarzyna Mleczko-Sanecka, Juri Rappsilber and Gracjan Michlewski
    Citation: BMC Biology 2025 23:24
    Content type: Research article Published on:

  8. Glioblastoma multiforme (GBM) is characterized by its cellular complexity, with a microenvironment consisting of diverse cell types, including oligodendrocyte precursor cells (OPCs) and neoplastic CD133 + radi...

    Authors: Mert Cihan, Greta Schmauck, Maximilian Sprang and Miguel A. Andrade-Navarro
    Citation: BMC Biology 2025 23:15
    Content type: Research article Published on:

  9. Vertebrates have one Dicer ortholog that generates both microRNAs (miRNAs) and small interfering RNAs (siRNAs), in contrast to the multiple Dicer-like proteins found in flies and plants. Here, we focus on the ...

    Authors: Kinga Ciechanowska, Agnieszka Szczepanska, Kamil Szpotkowski, Klaudia Wojcik, Anna Urbanowicz and Anna Kurzynska-Kokorniak
    Citation: BMC Biology 2024 22:287
    Content type: Research article Published on:

  10. The 3′ untranslated region (3′UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. Cap analysis of gene expression (CAGE), a method for the detection of capped 5′...

    Authors: Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M. Chakrabarti, Andrew M. Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R. Sibley…
    Citation: BMC Biology 2024 22:254
    Content type: Research Published on:

  11. Recent studies have shown that several long non-coding RNAs (lncRNAs) in the placenta are associated with preeclampsia (PE). However, the extent to which lncRNAs may contribute to the pathological progression ...

    Authors: Haihua Liu, Zhijian Wang, Yanjun Li, Qian Chen, Sijia Jiang, Yue Gao, Jing Wang, Yali Chi, Jie Liu, Xiaoli Wu, Qiong Chen, Chaoqun Xiao, Mei Zhong, Chunlin Chen and Xinping Yang
    Citation: BMC Biology 2024 22:159
    Content type: Research article Published on:

Submission Guidelines

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This Collection welcomes submission of original Research Articles. 

Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal.

To submit your manuscript to this Collection, please use our online submission system. During the submission process you will be asked whether you are submitting to a Collection, please select "Regulation of gene expression through RNA" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editor or Editorial Board Member who has no competing interests.